The ISPE GAMP® Good Practice Guide: Enabling Innovation - Critical Thinking, Agile, IT Service Management provides information to support the adoption of new and improved approaches to software engineering, data management, and "as a Service" offerings (XaaS), including the use of supporting tools. This helps regulated companies facilitate the best use of resources and encourages the application of appropriate and proportionate practices. This Guide discusses how critical thinking based on product and process knowledge and quality risk management can enable the removal of barriers to the introduction of new and innovative technologies. Practical considerations are presented, such as ways to increase the maturity level of an organization's critical thinking ability, the appropriate use of requirements management and traceability tools to eliminate duplicating documentation as audit evidence, and the use of scripted and unscripted testing for maximum effectiveness.